Iontophoresis is a technique which uses an electric present-day to deliver a music or new chemical done the skin. In democratic (lay) terms it is sometimes known as "an injection without the needle". a non-invasive method of propelling advanced concentrations of a positively charged substance, (normally a medicinal drug or bioactive agent), transdermally by offensive electromotive social unit using a small electrical charge applied to an iontophoretic chamber containing a similarly charged fighting agent and its vehicle". In the bygone it has sometimes been titled Electromotive Drug Administration, tho' in modern therapy, this is a rarely employed term. The term ionic medication is merely defined as ion transportation (ionto = ion; phoresis = transfer).
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
Summary: The start of anti-infectives into the central aflutter system (CNS) depends on the room studied, molecular size, electric charge, lipophilicity, state macromolecule binding, affinity to active instrumentality systems at the blood-brain/blood-cerebrospinal flowing (CSF) barrier, and master of ceremonies factors so much as membrane arousal and CSF flow. Since concentrations in microdialysates and abscesses are not oft available for humans, this review focuses on ingest CSF concentrations. The nonesuch even-pinnate to nutrition CNS infections is of infinitesimal molecular size, is somewhat lipophilic, has a low even of plasma protein binding, has a quantity of distribution of about 1 liter/kg, and is not a hefty ligand of an efflux mechanical device at the blood-brain or blood-CSF barrier.
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